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Aquilani has tallied one goal in 15 Serie A matches this season, while Gattuso has started only one game and his return to action has yet to be determined.
Milan enters the derby eight points clear of Inter, which resides in fifth place.
And another three points on Saturday for Real would pile even more pressure on the Catalan side ahead of Sunday's match with Real Betis before the two heavyweights meet up in midweek in the Copa del Rey.
"We shouldn't obsess about the tie," Casillas told the club's official website when asked about Wednesday's fixture with Barca.
Barca owns a 3-1 win over Real Madrid in December, but Mourinho's side bounced back from that defeat to win its next two league matches by a combined score of 11-3.
Mallorca has claimed only one win from its last five matches in the league but administered a 6-1 thrashing to Real Sociedad in the Copa del Rey on Wednesday.
Saturday's other fixtures feature Granada hosting Rayo Vallecano in a clash of bottom-half teams, last-place Real Zaragoza entertains Getafe and Sevilla tries to snap a three-game losing streak when Espanyol visits the Sanchez Pizjuan.
Kansas City, MO (Sportsbook Betting Lines) - The Atlanta Beat picked U.S. national team and UCLA forward Sydney Leroux No. 1 overall in the 2012 Women's Professional Soccer draft Friday. The 21-year-old Leroux scored 30 goals in 36 games for U.S. Under-20 national team from 2008-10. She made her debut for the U.S. senior side last year, when she was also a MAC Hermann Trophy semifinalist as the best college player.
"She is the best player in the draft without a doubt," said Beat manager James Galanis. "Not only based of her credentials but also just as a soccer player.
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MySportsbook.com Week 1 odds:
Saints +6 @ Colts -6
Falcons @ Vikings (pick ‘em)
Panthers @ Rams (pick ‘em)
Broncos -3.5 @ Bills +3.5
Chiefs -1 @ Texans +1
Dolphins +3 @ Redskins -3
Patriots -5 @ Jets +5
Eagles -3.5 @ Packers +3.5
Steelers -4 @ Browns +4
Titans +6 @ Jaguars -6
Bears +6 @ Chargers -6
Lions +3 @ Raiders -3
Bucs +6.5 @ Seahawks -6.5
Giants +4 @ Cowboys -4
Ravens +3 @ Bengals -3
Cardinals +3 @ 49ers -3
Super Bowl line (2008)
NFC +6.5 vs. AFC -6.5
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